The JAK2/STAT3 signaling pathway can promote EMT to enhance the migration and invasion abilities of ovarian cancer cells.19 It has been reported that the exosomal transfer of LCP1 promotes the tumorigenesis and metastasis of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway.20 Therefore, we speculate that the mechanism of PARPi resistance in ovarian cancer cells may be related to enhancement of the activity of this pathway. The gene discussed is JAK2; the disease is osteosarcoma.