IL17RA and digestive system infectious disorder: In various mouse models, including C57Bl/6, FVB/N, and now InsGAS, our studies consistently highlight the crucial role of IL-17RA in preventing exacerbated inflammation and the development of lymphoid follicles.21–23 While Il17ra-/- mice have been employed in many infection models, including those involving gastrointestinal infections, this represents one of the few instances where inflammation levels are notably elevated.