PIGR and infection: Gene expression of the polymeric immunoglobulin receptor (Pigr) is regulated by IL-17A in the intestines and in the stomach.22,53 To investigate if Pigr transcript levels were impacted in the InsGAStg/tgIl17ra-/- mice, real-time rtPCR wasperformed at 6 weeks, 3 months, and 6 months post-infection.