IL17A and cancer: In the established model of chronic H. pylori infection in C57Bl/6 mice (which did not lead to cancer development), IL-17RA deficiency results in reduced neutrophil recruitment and elevated bacterial burden.21 Paradoxically, the chronic inflammatory response is exacerbated, suggesting a potential regulatory role for IL-17 signaling in preventing hyperactivation of the adaptive immune response.21,22 IL-17RA signaling may protect against a prolonged pathogenic T cell response and thus, IL-17RA may prevent chronic activation of damaging inflammatory pathways.