Additionally, in a recent study which investigated N-methyl-N-nitrosourea (MNU) treatment and H. pylori infection in a mouse model of gastric cancer, IL-17A knockout mice did not develop as many gastric tumors and had a decrease in oxidative stress.38 Their results suggest that IL-17A promotes gastric carcinogenesis through IL-17RC/NFκB/NOX1 activation. This evidence concerns the gene IL17A and gastric cancer.