INS and obesity due to melanocortin 4 receptor deficiency: When this strain was administered to obese rats, it resultedin reduced food intake, body weight, and fat mass, as well as improvementsin glucose metabolism and insulin sensitivity.111 While those studies provided promising results, it is importantto note that NGPs for treating obesity are still in the early stagesof development, and much more research is needed before they can beused as a clinical treatment.