INS and obesity due to melanocortin 4 receptor deficiency: Studieshave investigated the potential of NGPs for treating obesity.In one study, researchers engineered a strain of Lactobacillusparacasei to produce a conjugated linoleic acid (CLA) isomerknown to promote weight loss in animals.110 Administering this strain to obese mice resulted in significantreductions in body weight and fat mass, as well as improvements inglucose metabolism and insulin sensitivity.