CNTF and early-onset autosomal dominant Alzheimer disease: The shared biomarkers between retinal and cognitive dysfunction are ADAM10 and CNTF, as they show promising diagnostic and therapeutic targets for cognitive impairment in neurodevelopmental psychiatric disorders interventions for multiple reasons: 1- Early diagnosis, as decreased CNTF and ADAM10 were detected in early stages of cognitive impairment in Alzheimer’s Disease patients and acute SSD.