IGHE and chronic rhinosinusitis with nasal polyps: The ROC curve analysis indicated that the predictive accuracy of ADAM8 levels in nasal secretions, with an AUC of 0.881 (P < 0.001), was superior for assessing the disease control status of CRSwNP when compared to peripheral blood eosinophil count (AUC = 0.709, P < 0.001), blood eosinophil percentage (AUC = 0.560, P = 0.333), serum total IgE levels (AUC = 0.737, P < 0.001), and FnNO (AUC = 0.635, P = 0.029) (Figure 6).