Studies found that patients with protein S deficiency were successfully treated with edoxaban [6,7] or rivaroxaban [8,9], protein C deficiency with rivaroxaban [10,11] or edoxaban [12,13], antithrombin deficiency with apixaban [14] or rivaroxaban [15], homozygous factor V Leiden mutation with rivaroxaban [16], and heterozygous factor V Leiden mutation with apixaban [17]. This evidence concerns the gene F5 and protein c deficiency.