Comparing the Average global expression profile of neutrophils from healthy PDL versus neutrophils from PDL with periodontitis revealed increased expression of genes such as Il1b, Il1rn, Cebpb, Colec12, Ptgs2, Zfp36, Egr1, Atf3, Csf1, and Lars2 in periodontitis (Figure 3C). Here, IL1RN is linked to periodontitis.