(5) Yellow clustering: this mainly focuses on the TME and tumor immune microenvironment, and keywords such as “immune metabolism” and “tumor microenvironment” appear as nodes and are linked to words such as “immunosuppression”, “immune evasion”, “immunotherapy”, “PD-L1”, “tumor-associated macrophages”, “macrophage polarization”, “regulating t-cells”, “t-cells”, “suppressor-cells”, “t-cell metabolism”, “immune cells”, “CD8(+) t-cells”, and “gut microbiota”. The gene discussed is CD274; the disease is neoplasm.