PrevAKI RCT [26]: Elevated TIMP-2*IGFBP7 linked to care bundle in post-cardiac surgery patients reduced the incidence of AKIPrevAKI-multicenter RCT [74]: Elevated TIMP-2*IGFBP7 linked to care bundle in post-cardiac surgery patients improved care bundle adherence and reduced the incidence of stage 2/3 AKIBigpAK RCT [27]: Elevated TIMP-2*IGFBP7 linked to care bundle in post-non-cardiac surgery patients reduced the incidence of stage 2/3 AKI. This evidence concerns the gene IGFBP7 and acute kidney injury.