Intriguingly, dual-luciferase reporter assays and qPCR analysis on mouse prefrontal cortex tissue revealed diminished expressions of both ESR1 and ESR2 in model mice afflicted with PPD, with ESR2 exhibiting a specific inhibitory interaction with the miR-10a promoter (Fig. 9B to F). The gene discussed is ESR2; the disease is progressive pseudorheumatoid arthropathy of childhood.