These findings were further validated by assessing the expression levels of key glutamate receptors (Figs. 4M to Q and 5M to Q), establishing a direct link between the modulation of the miR-10a-5p-BDNF pathway and the restoration of glutamatergic signaling in the context of PPD. This evidence concerns the gene BDNF and progressive pseudorheumatoid arthropathy of childhood.