BRAF and neoplasm: Considering the clinicopathological characteristics in our tumor samples, low mRNA values were associated with an increased risk of malignancy, and TCGA data analysis also showed an association between reduced FOXE1 mRNA expression and the aggressiveness of PTC subtypes, as previously reported (7), as well as with worse clinicopathological and genetics characteristics, such as extra thyroid invasion, AJCC and TNM classification, and the presence of BRAF mutations.