FOXE1 and skin neoplasm: FOXE1 expression has been studied in different tumor types: FOXE1 downregulation was observed in salivary gland, breast, colon, and skin tumors (15, 16, 18), upregulation was described in basal cell carcinoma, liver, and airway tumors (32–34), and, in pancreatic tumors, both increased and decreased FOXE1 expression was reported (17, 35, 40).