Recently, novel evidence has indicated that alterations in the intestinal microbiota (57) reduced cardiac expression of retinol dehydrogenase 10 (58) and upregulated lysine acetyltransferase 2 A (Kat2a) (59), both of which participate in ferroptosis in DCM and provide more therapy targets for DCM. This evidence concerns the gene KAT2A and familial dilated cardiomyopathy.