For example, the proportions of patients in the iSAP group with advanced age, atrial fibrillation, COPD, hyperhomocysteinemia, ESS, high NIHSS score, high KWDT score, high A2DS2 score, elevated white blood cell count, increased CRP levels, and higher fT4 levels were all significantly higher compared to the Control group (all P < 0.001). The gene discussed is CRP; the disease is atrial fibrillation.