Luteinizing hormone (LH), ovarian sex hormone levels decreased significantly, thus achieving the effect of inhibiting endothelial hyperplasia (65, 67–69); In addition, GnRH-a can directly bind to GnRH receptors on tumor cells, interfering with mitotic signaling, inducing a decrease in c-fos expression of oncogenes, and inhibiting tumor cell proliferation, thus inhibiting tumor growth (70, 71). This evidence concerns the gene GNRHR and neoplasm.