It can affect endometrial cancer cells through multiple signaling pathways and multiple molecular targets, such as the CACNA2D3 gene, Wnt/β-catenin, PI3K/Akt, LncRNANEAT1/miR-146b-5p, PDCD4, and TGF-β/Smads, to influence endometrial cancer cell proliferation, apoptosis, invasion and metastasis, thus exerting anti-tumor effects (107–111). The gene discussed is TGFB1; the disease is endometrial cancer.