The positive finding of MDM2 and CDK4 in immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) contribute to the correct diagnosis of DDLPS because i) DDLPS differential diagnosis is widespread from benign to malignant tumors and ii) DDLPS rarely showed heterogeneous differentiation (3). This evidence concerns the gene MDM2 and dedifferentiated liposarcoma.