Moreover, previous studies have indicated that the KEAP1-NRF2 pathway is dysregulated in ALS animal models (Bono et al., 2021; Mimoto et al., 2012), as well as in postmortem ALS motor cortex/spinal cord samples and a reduction in both NFE2L2 mRNA and NRF2 protein has been observed in ALS patient tissues (versus healthy controls) (Sarlette et al., 2008). Here, NFE2L2 is linked to amyotrophic lateral sclerosis.