Moreover, considerable evidence suggested the existence of common downstream pathways, at least for some ALS-related genes such as SMN1/FUS (Yamazaki et al., 2012), TDP43/ATXN2 (Elden et al., 2010) or PFN1/TDP43 (Wu et al., 2012). This evidence concerns the gene PFN1 and amyotrophic lateral sclerosis.