TARDBP and amyotrophic lateral sclerosis: It is thus tempting to hypothesize that those alterations in miR-10b-5p expression resulting from specific mutations in ubiquitously expressed genes (as TARDBP, FUS, C9ORF72 or SOD1) or in sporadic cases of ALS might be represented as active participants in the convergence of different ALS target genes on common pathways.