SOD1 and amyotrophic lateral sclerosis: Along this line, in our MN datasets we also found that miR-181c-3p was strongly upregulated in the MNs of SOD1- and TARDBP-ALS, whereas miR-124-3p blood biomarker was specifically expressed in SOD1-MNs, suggesting an independent regulation/mechanism of specific miRNAs in the different compartments.