SOD1 and amyotrophic lateral sclerosis: In fact, our enrichment analysis showed a downregulation of several CDKs target genes involved in cell cycle and stress response processes in SOD1. That would also explain the increased expression of miR-10b-5p in mutated MNs and consequent downregulation of CDKs may contribute to prevent the re-entry in cell cycle at early disease onset, thus suggesting a protective role in the SOD1-ALS.