SOD1 and amyotrophic lateral sclerosis: When the three differential gene expression analysis methods were combined, a set of 7 (SOD1) and 6 (TARDBP) DE-miRNAs was (fold change ≥ 1.5, p ≤ 0.05) shared in ALS patients compared to controls (15 and 12 DE-miRNAs in DESeq2, 10 and 14 DE-miRNAs in limma-voom, 10 and 8 DE-miRNAs in quantile normalization) (Figures 1A,B), and from those miRNAs, upregulation of miR-10b-5p and miR-181c-3p was commonly found between SOD1 and TARDBP mutant MNs.