A third phenotype has been suggested following the identification of the MEFV gene, with the presence of biallelic pathogenic variants with no clinical signs nor increased inflammatory markers.3 Systematic reviews have defined a wide range of symptoms associated with FMF; the well-known classical manifestations are fever, serositis with abdominal and chest pain, arthritis, and erysipelas-like erythema.4 This evidence concerns the gene MEFV and familial Mediterranean fever.