MYH9 and Macrothrombocytopenia: The MYH-9 gene is also implicated in MYH9-related diseases (MYH9-RD) which include the following diseases: MHA, Fechtner Syndrome, Sebastian Syndrome, and Epstein Syndrome.6, –8 These disorders all share the characteristics of macrothrombocytopenia and characteristic leukocyte inclusions and are classified as autosomal dominant platelet disorders.8 Common clinical symptoms include sensorineural hearing loss, presenile (early) cataracts, and renal failure due to nephropathy.6,7,9