It is worth mentioning that the combination of paeonol and glycyrrhizic acid has also been confirmed, which can effectively ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway (Zhang et al., 2024), and provides a new drug combination idea for the treatment of migraine. This evidence concerns the gene PRKACA and migraine disorder.