Paeonol also inhibited breast cancer cell invasion by suppressing the signaling pathway of the gene encoding the Notch-1 one-way transmembrane receptor and reduced the expression level of transgelin two in MCF-7/PTX cells, thereby reversing the resistance of breast cancer cells to paclitaxel (Cai et al., 2014; Zhang et al., 2016). This evidence concerns the gene NOTCH1 and breast carcinoma.