For example, in vitro experiments showed that angiogenesis is intimately related to the development of psoriasis, and paeonol can play a therapeutic role in psoriasis-related inflammation by modulating the VEGFR2/Akt/ERK1/2 pathway and effectively inhibiting cellular activity and lumen formation promoted by VEGF, thereby restraining angiogenesis (Luan et al., 2022). Here, MAPK3 is linked to psoriasis.