EAF2 and VHL double deficiency (EAF2−/−VHL+/−) mice exhibited increased vascular density compared to the control groups (wild-type, EAF2−/− and VHL+/−mice), thus resulting in a higher incidence of prostatic intraepithelial neoplasia and stromal inflammation. This evidence concerns the gene EAF2 and prostate intraepithelial neoplasia.