Then, based on the results observed in LNCaP cells, they found that (1) EAF2 knockdown elevated FOXA1 level, stimulated expression of AR-targeted genes, and promoted tumor proliferation and invasion, (2) FOXA1 knockdown inhibited the expression of AR-targeted genes and tumor proliferation, and (3) the joint knockdown of EAF2 and FOXA1 slightly increased AR-targeted gene expression and tumor proliferation. Here, AR is linked to neoplasm.