Biologically, research on human CRC cells in vitro has yielded three key findings: (1) overexpression of EAF2 suppresses the invasion and migration of CRC cells, (2) reduces the activity of STAT3/TGF-β1 crosstalk pathway, and (3) inhibits CRC angiogenesis. This evidence concerns the gene TGFB1 and colorectal carcinoma.