The significant SOCs associated with ICIs included gastrointestinal disorders (ROR025 = 1.30, SOC 10017947), respiratory, thoracic and mediastinal disorders (ROR025 = 1.41, SOC 10038738), metabolism and nutrition disorders (ROR025 = 2.27, SOC 10027433), skin and subcutaneous tissue disorders (ROR025 = 1.17, SOC 10040785), hepatobiliary disorders (ROR025 = 2.86, SOC 10019805), renal and urinary disorders (ROR025 = 1.42, SOC 10038359), blood and lymphatic system disorders (ROR025 = 1.81, SOC 10005329) and endocrine disorders (ROR025 = 10.50, SOC 10014698). Here, CISH is linked to lymphatic system disorder.