These results suggest that maternally acquired Abs from JEV-EWT mRNA-LNP-immunized female mice can accelerate the death of 1-day-old mice during ZIKV infection, while the maternally acquired Abs against JEV-Emut protein do not exacerbate the death of 1-day-old mice infected with ZIKV, but rather slightly improve the percent survival of mice, suggesting that Abs induced by JEV-Emut mRNA immunization may not make the host develop severe diseases after ZIKV infection. Here, DDX41 is linked to Zika virus infectious disease.