Considering that IgG in the mother’s body can across the placenta and enter the body of fetus or newborn, as well as that many women who have been infected with JEV or vaccinated with JEV vaccine will have children who may subsequently be infected with ZIKV, we then evaluate the impact of anti-JEV Abs obtained by the pups from the female mice vaccinated with either JEV-EWT mRNA-LNP or JEV-Emut mRNA-LNP on subsequent ZIKV infection. This evidence concerns the gene DDX41 and Zika virus infectious disease.