Studies have identified squalene epoxidase (SQLE) as a key regulator of various physiological processes, including cholesterol biosynthesis (Parris et al., 2014; Padyana et al., 2019), modulation of the gut microbiota (Li et al., 2022a), and the regulation of tumor immunity (You et al., 2022). The gene discussed is SQLE; the disease is neoplasm.