CYP24A1 and colorectal carcinoma: He et al. (2021) revealed that SQLE deficiency in CRC reduces intracellular cholesterol levels and decreases osteotriol (the active form of vitamin D3), leading to reduced levels of cytochrome P450 family 24 subfamily a member 1 (CYP24A1), the inhibition of ERK phosphorylation and CRC cell proliferation.