However, although the prognostic relevance of NSE had been discussed for several types of cancer, such as SCLC, non-small-cell lung cancer (NSCLC), prostate cancer (PC), small cell carcinoma of the urinary bladder (SCCB), and pancreatic neuroendocrine tumors (NETs) (Bremnes et al., 2003; Pujol et al., 2001; Yao et al., 2016; Fan et al., 2017; Naito et al., 2017), its association with CRC survival has not been effectively explored so far. This evidence concerns the gene ENO2 and small cell lung carcinoma.