The upregulation of MYDGF in the kidneys of mice with AAV9 transfection (Figure S3a, Supporting Information) reduced the levels of serum creatinine and blood urea nitrogen (Figure 3b), attenuated tubular injury and tubulointerstitial fibrosis in mice with AAN, which was confirmed by the reduced Collagen I and Collagen IV, Vimentin and α‐SMA levels (Figure 3c,d). Here, MYDGF is linked to Balkan nephropathy.