MYDGF is originally recognized as a paracrine protein mainly secreted by bone marrow‐derived monocytes and macrophages, and recombinant MYDGF has protective effects in the cardiovascular system including myocardial infarction,[7] and atherosclerosis.[10b] Emerging evidence has indicated that MYDGF is also expressed in parenchymal cells and plays important roles such as endothelial cells.[13] In the kidney, although studies have reported the contribution of exogenous recombinant MYDGF to maintaining kidney function, several aspects need to be further considered. The gene discussed is MYDGF; the disease is myocardial infarction.