At the molecular levels, Mydgf overexpression reduced the expressions of α‐SMA, Vimentin, and Collagen I in the kidney from UUO mice (Figure 7e,f; Figure S6b, Supporting Information), suggesting that tubular MYDGF may be a central target molecule that protects against kidney fibrosis in CKD. The gene discussed is MYDGF; the disease is chronic kidney disease.