Importantly, IDH2 was reduced in the tubules of patients with CKD (Figure 5c), and the level of IDH2 in the kidney negatively correlated with the expression of Vimentin and α‐SMA but positively correlated with MYDGF expression and eGFR (Figure 5d–g), suggesting that IDH2 might be a key target in MYDGF‐mediated mitochondrial homeostasis. This evidence concerns the gene MYDGF and chronic kidney disease.