Using different animal models of CKD, we found that MYDGF expression was reduced in the cortex of the kidney of mice with aristolochic acid nephropathy (AAN), unilateral ureter obstruction (UUO), folic acid nephropathy (FAN) and bilateral renal ischemia‐reperfusion injury (BIRI) (Figure1a; Figure S1a, Supporting Information). Here, MYDGF is linked to chronic kidney disease.