It is known that MYDGF derived from bone marrow cells, particularly monocytes and macrophages, protects against myocardial infarction,[7] pressure overload‐induced heart failure,[9] atherosclerosis,[10] interstitial tissue damage,[11] and diabetic kidney disease.[12] However, emerging evidence has also revealed new aspects of MYDGF function in parenchymal cells. This evidence concerns the gene MYDGF and heart failure.