YTHDF1 and cancer: YTHDF1 overexpression downregulated the pathways associated with cancer immunity, including “Allograft rejection” from the hallmark gene set, “Natural killer mediated cytotoxicity” from the KEGG gene set, and “Positive regulation of NF‐kappa B signaling” from the GO gene set (Figure 3E,F; Figure S3D, Supporting Information).