IGFBP2 and Down syndrome: Such diagnoses include CNV syndromes with neurodevelopmental disorder risk like 22q11.2 deletion [OMIM #188400]/duplication [OMIM #608363] syndromes, 16p11.2 deletion syndrome [OMIM #611913], 15q11.2 deletion (BP1‐BP2) [OMIM #615656], and 8p23.1 duplication syndrome; these syndromes are challenging to identify without overt syndromic features and/or early in childhood but have longer‐term management implications (Vanlerberghe et al. 2015; Davis et al. 2019; Yu et al. 2019; Steinman et al. 2016; Barber et al. 2013).