FN1 and Cachexia: Multivariable logistic regression was used to estimate the associations between Fn abundance with onset of cachexia while adjusting for important covariates including age based on median age at diagnosis (< 65 years old and ≥ 65 years old), stage at diagnosis (I and II, III), tumor site (colon, rectum), and recruitment center (HD, Germany, or HCI, USA) based on stepwise selection procedure.