Several studies have shown that fecal Fn abundance or Fn abundance in the tumor play a significant role in promoting CRC risk [11, 12, 13, 14, 15], as well as CRC recurrence, poorer prognosis, and chemotherapy resistance [11, 16, 17, 18, 19, 20, 21]. The gene discussed is FN1; the disease is colorectal carcinoma.