Multivariable logistic regression was used to estimate the associations between Fn abundance with onset of cachexia while adjusting for important covariates including age based on median age at diagnosis (< 65 years old and ≥ 65 years old), stage at diagnosis (I and II, III), tumor site (colon, rectum), and recruitment center (HD, Germany, or HCI, USA) based on stepwise selection procedure. The gene discussed is FN1; the disease is neoplasm.