We examined all the variants that are 1 MB upstream or downstream to the top GWAS variant in this locus and using GCTA-COJO, we show that an intronic CTSB variant (rs1293298, p = 3.41E-16, located in intron 1 of CTSB within a potential enhancer region) is the top variant associated with PD risk, without secondary associations. This evidence concerns the gene CTSB and Parkinson disease.