Consistent with the in vitro results (n = 20), rGDPP administration increased the development of CRPC tumor in the BM compared to that in control mice, as evidenced by the significant increase of ROI, tumor volume, and Ki67-positive cells (p = 0.0343, p = 0.0412, and p = 0.0445, respectively, Fig. 6E-G). This evidence concerns the gene MKI67 and neoplasm.