In addition, analysis of bulk RNA-seq data from The Cancer Genome Atlas (TCGA) database showed that the expression levels of GDF15 were the highest, and those of Furin, which cleaves the junction between the GDPP domain and the remainder of the mGDF15 sequence, were relatively higher in PCa than in other cancer types (Fig. S1D, S1E). This evidence concerns the gene FURIN and cancer.