Moreover, by analysing transcriptomics and proteomics datasets of human PDAC [35], we found that Slc3a2 and Lamin B1 were significantly elevated in PDAC tissue when compared to the normal tissue counterpart, thus indicating a positive role of these genes in pancreatic cancer progression (Fig. 3G, H). This evidence concerns the gene SLC3A2 and familial pancreatic carcinoma.