CXCR4 and colorectal carcinoma: Collectively, these findings suggest that β-catenin functions as a downstream regulatory target of miR-1269a, PCDHGA9, and CXCR4, which collectively constitute the miR-1269a/PCDHGA9/CXCR4/β-catenin pathway, which can be targeted to prevent CRC invasion and metastasis (Fig. 7f).