CXCR4 and colorectal carcinoma: Furthermore, we investigated the role of PCDHGA9 in reducing the invasive and metastatic tendencies of CRC, explored miR-1269a as an explanatory factor for the diminished PCDHGA9 levels in CRC, and revealed the intricate interplay among the constituents of the miR-1269a/PCDHGA9/CXCR4/β-catenin axis, delineating their roles and cumulative effects on the invasive and metastatic functions of CRC.