PCDHGA9 and colorectal neoplasm: To further investigate the underlying cause for the reduced PCDHGA9 expression in colorectal tumors, we conducted a comprehensive analysis to predict the upstream regulatory microRNAs of PCDHGA9 using the StarBase, TargetScan, and miRBD bioinformatics tools, which identified hsa-miR-1269a and hsa-miR-3179 as common target microRNAs predicted by all three tools (Fig. 3a).