MYC and lung cancer: Accordingly, gene set enrichment analysis (GSEA) of the transcriptomic data showed that the Hallmark of MYC targets V1 and V2 are both significantly upregulated in human A549-rtTA-OSKM and mouse L1475luc-rtTA-OSKM lung cancer cell lines (Fig. 3A, B and Fig. S4B, C), consistent with OSKM expression.