Of note, this reduction in the luciferase signal inversely correlates with a significant increase in apoptosis markers in L1475luc-rtTA-OSKM cells (cleaved caspase 3+ ratio to tumor area 0.215 ± 0.109) relative to L1475luc-rtTA cells (cleaved caspase 3+ ratio to tumor area 0.078 ± 0.033%, p < 0.0001) (Fig. 6F, G) concomitant with a trend of higher p21 expression in L1475luc-rtTA-OSKM cells (p21+ 0.694 ± 0.227%) relative to L1475luc-rtTA cells (p21+ 0.579 ± 0.184%, p = 0.138) (Fig. 6H, I). This evidence concerns the gene CASP3 and neoplasm.