CCN5 and cardiac hypertrophy: LncRNA-chast (cardiac hypertrophy-associated transcript) has been shown to regulate cardiac hypertrophy at the cardiomyocyte level [46]. Similarly, lncRNA-wisper (Wisp2 super-enhancer-associated RNA) has been identified as a cardiac fibroblast-enriched lncRNA, regulating fibrosis after cardiac injury and correlating with fibrosis in both mice and human hearts with aortic stenosis [47].