TLR7 and psoriasis: ,73 Given that c-Rel deficient DCs are unable to produce inflammatory cytokines including IL-1β and IL-6 (Fig. 3, Fig. 6b and c), we hypothesised that the TLR7/c-Rel signalling axis in DCs regulated the induction of naïve T cells to differentiate into Th17 cells during psoriasis.