The role of c-Rel has also been shown in TLR2, 3, 4, 6, and 9-induced activation of the IL-23p19 promoter,5 however there is a lack of knowledge regarding the potential role of c-Rel in TLR7 signalling, and the possibility of this signalling axis being involved in the development of psoriasis. The gene discussed is TLR7; the disease is psoriasis.