The relevance of the IMQ-induced psoriasis mouse model to human disease has long been discussed.84, 85, 86 The translation of the IMQ-induced psoriasis mouse model to human disease, and thus the necessity of TLR7 signalling in psoriasis, has been questioned due to IMQ treatment inducing psoriasis in TLR7 KO mice.87 The gene discussed is TLR7; the disease is psoriasis.