To further investigate whether Trim72 replenishment could modify the progression of C. albicans infection, we treated WT mice with different doses of recombinant murine (rm) Trim72 protein (62.5, 125 or 250 μg/kg) upon systemic C. albicans infection, and injected 31, 62.5, 125 μg/kg rmTrim72 respectively at 2 days after infection (Fig 3A). Here, TRIM72 is linked to infection.