METTL3 and infection: Moreover, endogenous Co-IP further validated the METTL3-NP interaction in SFTSV-infected Huh7 cells (S5C Fig), and confocal microscopy analysis also revealed that SFTSV infection resulted in the translocation of endogenous or exogenous METTL3 from the nucleus to the cytoplasm, where it colocalized with the SFTSV NP (Figs 4C and S5D).