Golgi-resident site-1 protease (S1P), LXR (α, β), LDL receptor (LDLR), ATP-binding cassette transporter A1 (ABCA1), and lysosomal acid lipase (LAL) have been suggested involving in the relationship between cholesterol metabolism and osteoporosis [3, 35]. The gene discussed is MBTPS1; the disease is osteoporosis.