Oxidized LDL (oxLDL), which is critical in the initiation and progression of atherosclerosis, had also been reported to be linked to osteoclastogenesis, bone resorption, and osteoblast demineralization through elevating levels of the receptor activator of NF-kappaB ligand (RANKL), or inhibiting phosphate signaling and phosphate-induced mineralization [36, 37]. The gene discussed is TNFSF11; the disease is atherosclerosis.