Usually, the promoters myh6 and myh7 are used to drive cardiomyocyte-specific gene expression or deletion for CHD studies (43, 44), so CHD caused by endothelial cell abnormalities might be grossly underestimated, although nearly one-third of heart cells are endothelial either in humans or in mice (15, 17). This evidence concerns the gene MYH6 and coronary artery disorder.