SPARC-related modular calcium-binding protein 1 (SMOC1) has been shown to be one of the most dysregulated proteins in Alzheimer’s disease (AD) brain tissue, cerebrospinal fluid (CSF), and plasma in 23 proteomic analyses to date [8, 9, 21, 27, 28, 36, 45, 50, 53, 65, 66, 87, 88, 96, 98, 99, 102, 104, 115, 117, 119, 120, 127]. This evidence concerns the gene SMOC1 and early-onset autosomal dominant Alzheimer disease.