SMOC1 and amyloidosis: Despite significantly different total amyloid plaque loads in the temporal cortex and hippocampus (p < 0.0001) (Fig. 2a), a similar degree of SMOC1 colocalization with amyloid plaques was observed (43.8 ± 2.4% and 46.9 ± 6.8%, respectively, p = 0.962) (Fig. 2b).