SMOC1 is significantly increased in the CSF of AD patients when compared to cognitively normal controls [27, 30, 36, 45, 48, 50, 53, 96, 109, 115, 117, 127] or other neurodegenerative diseases [29, 45, 77, 98, 107, 112, 120]. Here, SMOC1 is linked to neurodegenerative disease.