Proteins with EF-hand calcium-binding domains similar to SMOC1 such as calbindin, parvalbumin, S100B, and calretinin have all been implicated in AD [7, 17, 20, 26, 51, 55–58, 78, 86, 93, 100, 103, 124]. This evidence concerns the gene CALB1 and Alzheimer disease.