To determine this, we performed immunohistochemistry on temporal cortex FFPE sections from n = 12 AD, n = 12 MCI, n = 10 preclinical AD, and n = 12 age- and sex-matched control cases to determine when SMOC1 accumulates in AD, and if SMOC1 colocalizes with amyloid plaques in early stages of AD. The gene discussed is SMOC1; the disease is Alzheimer disease.