Proteomic studies have established that SMOC1 levels in the human brain and CSF strongly correlate with Aβ levels [9, 36, 48, 50, 96, 98, 102, 115, 117, 127] and SMOC1 has been identified as a strong AD-specific biomarker candidate either in isolation [48, 117, 127] or within a protein panel [48, 50, 87, 109]. This evidence concerns the gene SMOC1 and Alzheimer disease.