In addition, the observed reduction in PRO-C4 not only paralleled INT-767 antifibrotic efficacy but also correlated strongly with type I collagen, type IV collagen, and laminin tissue content (Supplemental Figure S2D, http://links.lww.com/HC9/B86), emphasizing its utility as a circulating biomarker of hepatic ECM deposition in MASH. The gene discussed is C4A; the disease is metabolic dysfunction-associated steatohepatitis.