For instance, Lecanu et al. demonstrated that infusing Fe2+, Aβ42, and buthionine-sulfoximine (FAB), but not Aβ42 alone or in combination with Fe2+, into the left cerebral ventricle of Long-Evans rats for 4 weeks led to memory impairment and increased levels of hyperphosphorylated Tau protein in CSF [16]. This evidence concerns the gene MAPT and memory impairment.