Consistent with transcriptomic and proteomic profiles, F3-8 EVs (and to some extent, F3-8 MVs/“microvesicles”) promoted expression of OAS1-3, MDA5/IFIH1, and RIG-I/DDX58, overall relative to EVs from other tumor cell lines, including G17-1 EVs. This evidence concerns the gene RIGI and neoplasm.