Curiously, Rigg, Wang et al. [88] demonstrated a role for miR-146a-5p in EVs from melanoma brain metastasis EVs in dysregulating NOTCH in astrocytes, leading the astrocytes to release pro-inflammatory/pro-tumor cytokines (IL6, IL8, MCP-1/CCL2 and CXCL1). The gene discussed is CCL2; the disease is melanoma.