The F3-8 EV-treated astrocyte proteome highlights the cyto/chemokine influences driven by signal transducer and activators of transcription (STAT) activation and IFN-related molecular upregulation (Figure 2A), emphasized by the components of the “Role of Hypercytokinemia/Hyperchemokinemia in Influenza Pathogenesis” and “Interferon Signaling” pathways, which show high significance. The gene discussed is IFNA1; the disease is influenza.