Additionally, M2 macrophage-derived EVs contain lncRNA NORAD, which is delivered to acceptor NSCLC cells to boost their proliferation by binding to miR-520g-3p, thereby stabilizing small integral membrane protein 22 (SMIM22) and UDP-galactose-4-epimerase (GALE) [55]. Here, SMIM22 is linked to non-small cell lung carcinoma.