C9orf50 and breast cancer: However, in a study that aimed to elucidate potential RNA biomarkers comparing plasma EVs from 32 patients with locally advanced breast cancer when diagnosed or 7 days post-surgery and also with 30 healthy individuals, the authors constructed a signature of eight RNAs (SNORD3H, SNORD1C, SNORA74D, miR-224-5p, piR-32949, lnc-IFT-122-2, lnc-C9orf50-4, and lnc-FAM122C-3) capable of discerning breast cancer from healthy EVs [73].