Our purpose was to provide an endocrine perspective of a case series diagnosed with RET-positive familial medullary thyroid carcinoma associated with cutaneous primary lichen amyloidosis (six members of the same family had the cutaneous lesion and four of them were investigated and proved to carry the 634 codon pathogenic variant at exon 11) amid the confirmation of multiple endocrine neoplasia type 2. The gene discussed is RET; the disease is multiple endocrine neoplasia type 2.