For example, the autoantibodies towards Dsc3 [31,32,33,34,35,36,37,38,39], M3 muscarinic acetylcholine receptor (M3AR) [40,41,42,43], and secretory pathway Ca2+/Mn2+-ATPase isoform 1 (SPCA1) [40] corresponded with disease activity in patients with PV, and their pathogenic roles were demonstrated both in vitro and in vivo [40]. The gene discussed is DSC3; the disease is acquired polycythemia vera.