Abdominal pain [1]; carpal tunnel syndrome [1]; flatulence [1]; facial edema [1]; headache [1,47]; nausea [1]; insulin resistance [20,53] and possible type 2 diabetes [1,20]; cardiac instability [20,53]; hypertension [20,46]; sleep apnea [47]; abnormal bone growth [53] [46,47]; muscle weakness [46]; fluid retention [46]. The gene discussed is INS; the disease is hypertensive disorder.