The literature has controversially demonstrated the association between MTHFR C677T and MTHFR A1298C genotypes with breast cancer in female populations from different geographical regions such as China and Egypt, but underlining the increased risk of breast cancer in Caucasian women [18,28,31], while prothrombotic coagulation factors, FVL and FII, were not significantly associated with family history of colorectal cancer [32]. This evidence concerns the gene MTHFR and breast cancer.