SP1 and connective tissue disorder: In this sense, Wang, C et al. [33] reported that the COL1A1 Sp1 rs1800012 T/T polymorphism is associated with various connective tissue disorders affecting the properties of type I collagen, which causes a greater risk of injuries such as osteoarthritis, osteoporosis, and soft tissue injuries such as rupture of the anterior cruciate ligament [33,34].