SQLE and dermatophytosis: Many cases of T. indotineae dermatophytosis are recalcitrant to both topical and oral preparations of first-line treatment option terbinafine because a large number of isolates demonstrate in vitro elevated MICs to terbinafine (MIC ≥0.2 μg/mL) due to point mutations causing amino acid substitutions in squalene epoxidase (SQLE) (5, 7, 10, 14, 15).